The website of Science Translational Medicine, a prestigious international academic journal, recently published the latest research results from the team of ye haifeng, a researcher at east China normal university. The study is the first to achieve the treatment of diabetes through ultra-remote control of smart phones, and it is expected to provide new ideas and strategies for the future clinical integration and precision treatment of diabetes.
In recent years, with the continuous innovation of mobile communication technology, the rapid development of intelligent mobile phones has become an indispensable part of operation medical care and has been used in blood glucose monitoring. However, there are only diagnostic and detection functions for diabetics, and no treatment can be achieved. Therefore, east China normal university college of life science researcher Ye Haifeng team will ably combined with electronic engineering, synthetic biology has developed a set of diabetes diagnosis and treatment for the integration of new intelligent diagnosis system.
A new system of intelligent diagnosis and treatment of diabetes diagnosis and treatment
The system has two main features: first, the researchers can control the gene expression by using the mobile phone ECNU-TeleMed app to control the far-red light brightness. Second, diabetic white mice can be translated into far-red brightness to regulate gene expression.
The engineered cells that control the far-red response through the smart phone reach the schematic diagram of the semi-automatic treatment of diabetes
First, the researchers used synthetic biology concept, designed and synthesized far red regulate gene expression of customized cell, the transformation under the irradiation of cells in the far red, can produce any desired report protein genes or drugs, such as green fluorescent protein or insulin.
When researchers will far red control insulin expression of customized cell transplantation to the diabetic mice subcutaneously to diabetic mice direct far red light, you can start the subcutaneous transplanted cells produce insulin, and the effects of a good. Using the treatment, diabetic rats can keep their blood sugar at normal levels for up to half a month, just two to four hours a day.
The researchers adopted a multi-disciplinary approach to design and develop an integrated intelligent control system for diabetes diagnosis and treatment. Using a blood glucose meter to measure the rat's blood sugar, it can be wirelessly beamed to a special Smart Controller and a Smart phone. When blood sugar blood sugar levels higher than the pre-set safety threshold, the intelligent controller can light up transplantation in mice, customized cells contain composite hydrogel leds (LED) Hydroge, triggering customized cells produce insulin or glp-1, reach the role of fall blood sugar and maintain a stable blood sugar. In addition, when the cell phone shows an abnormality, it can also control the intelligent controller and optimize the treatment.
Mark Gomelsky, a molecular biologist at the university of Wyoming, wrote a commentary on the study. He says wearing a LED bracelet can make the same effect easier than putting a disk into human skin. However, the modified cells still need to be injected into the body alone, and it is not clear how long it will take for the cells to be injected.
Gomelsky professor, east China normal university of technology may not be the best way to treat type 1 diabetes, after all, the United States food and drug administration (FDA) last year just approved the first automatic insulin syringe. But he says the technology could be used to control cells to produce genetically modified drugs for other diseases.
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